Sulphydryl requirement for insulin release from the perfused pancreas
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چکیده
منابع مشابه
Effect of age and environmental factors on insulin release from the perfused pancreas of the rat.
In this study we examined the effect of age and various age-related environmental factors on maximal glucose-stimulated insulin release by the intact perfused pancreas. Male Sprague-Dawley rats were maintained from 40 d to 12 mo of age on standard chow, or on a sucrose-rich or calorie-restricted diet. At 12 mo, studies were carried out on the isolated pancreas of each animal to determine maxima...
متن کاملEffect of from the Sustained Hyperg Isolated Perfused lycemia on the Rat Pancreas Release of Insulin
The modulation of insulin release from the isolated pancreas using normal rats rendered hyperglycemic by in vivo glucose infusion was studied. In 24 h and 48 h hyperglycemic rats , the increase i n the amount of insulin released was reduced in response to glucose challenge , but was unchanged in relation to arginine challenge. In 48 h hyperglycemic rats insulin secretion after glucagon challeng...
متن کاملRequirement for calcium ion in insulin secretion by the perfused rat pancreas.
CURRY, DONALD L., LESLIE L. BENNETT, AND GEROLD M. GR~DSKY. Requirement for calcium ion in insulin secretiorz by the perfused rut p ancreas. Am. J. Physiol. 214(l): 174-178. 1968.The effect of calcium ion on insulin release was studied in the isolated perfused rat pancreas. Following a standard glucose stimulus, insulin secretion (determined by immunochemical assay of the total portal vein effl...
متن کاملKinetics of insulin release from the perfused rat pancreas caused by glucose, glucosamine, and galactose.
Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all likelihood common sites of action, it is postulated that a glucoreceptor of broad specificity is inv...
متن کاملEffect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas.
This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 +/- 4 pg/ml. Basal insulin release was less than 20 microU/ml. High glucose (300 mg/dl) conditio...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1978
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf03160999